Endothelium and cardioprotective effects of hmg-co-a-reductase in combination with L-arginine in endothelial dysfunction modeling

Using the combined application of L-arginine with HMG-Co-A reductase inhibitors simvastatin, atorvastatin, rosuvastatin and nanoparticulated on background modeling sepsis-induced disease through introduction strain 603 Staphylococcus aureus shows endotelio- cardioprotective effects, manifesting itself in preventing proliferation endothelial dysfunction coefficient (CED), adrenoreactivity, maintenance myocardial reserve normalization biochemical markers values (Total NO, eNOS expression, C-reactive protein, IL-6, TNF). In this case, therapy was so effective that obtained thereunder did not differ from those control animals.